| 摘要 |
A METHOD FOR THE RAPID SCREENING OF ANALYTES, SUCH AS PROTENTIAL DRUG CANDIDATES, COMPRISES THE STEPS OF APPLYING A PLURALITY OF ANALYTES TO BE SCREENED ONTO ONE OR MORE SOLID SUPPORT (S) (61) SUCH THAT THE ANALYTES REAMIN ISOLATED FROM ONE ANOTHER; CONTACTING SAID ANALYTE-CARRYING SOLID SUPPORT(S) (61) WITH TARGETS PROVIDED IN A SEMI-SOLID OR LIQUID MEDIUM, WHEREBY SAID ANALYTES ARE RELEASED FROM THE SOLID SUPPORT(S)(61) TO THE TARGETS; AND MEASURING ANALYTE-TARGET INTERACTIONS. THIS METHOD ALLOWS FOR THE MAINPULATION OF THOUSANDS OF DIFFERENT ANALYTES SIMULTANEOUSLY. WHEN THE ANALYTE IS APPLIED TO THE SOLID SUPPORT (61) IT CAN DIFFUSE THEREON SO AS TO PRODUCE A CONCENTRATION GRADIENT AND SERIAL DILUTION OF ANALYTE IF A DOSE RESPONSE CURVE FOR A CANDIDATE DRUG IS REQUIRED. THE METHOD DESCRIBED CAN BE READILY AUTOMATED.(FIG. 20)
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