COMPOUNDS OF BICYCLIC HETEROAROMATIC DERIVATIVES

摘要

Bicyclic heteroaromatic derivatives of formula (1) are described: F (1)where: the dashed line joining A and C(R) is present and represents a bond and A is a -C(R) group; X is an -O-, -S-; Y is a -CH= group or C(R) group; n is zero or the integer 1; Alkis an alkylene chain; Lis a covalent bond ; Cyis a hydrogen atom or an optionally substituted Cphenyl, furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, pyridyl, pyrimidinyl, triazinyl or indolylgroup; Ar is an optionally substituted phenyl, furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, pyridyl, pyrimidinyl or triazinyl group, wherein Cyoptional substituents are selected from Calkyl, haloCalkyl, Calkoxy, haloCalkoxy; cyano –(CN), =COCH, -OC(CH), nitro –(-NO), amino (-NO), NHCH, -N(CH), -C(O)CHand –NHCOCH; and the salts, solvates, hydrates and N-oxides thereof.The compounds are potent and selective inhibitors of p38 kinase and are of use in the prophylaxis and treatment of immune or inflammatory disorders.