METHOD FOR TREATING DISSEMINATED FORMS OF MELANOMA

摘要

FIELD: medicine, oncology. ^ SUBSTANCE: the present innovation deals with treating disseminated forms of melanoma along with metastases into regional lymph nodes and intracutaneous metastases, the diameter being up to 2 cm at the depth of location up to 1 cm together with a locus. The method deals with intravenous injection of anti-tumor preparation as a photosensitizer (PS) of chlorine class into cubital vein of one hand at the dosage of about 1.5 - 2.0 mg/kg for 40-60 min and simultaneously, fulfill intravenous laser blood irradiation (IVLBI) into cubital vein of another hand at wave length corresponding to the maximal absorption of light radiation with PS, at the dosage of irradiation being 600-900 J/sq. cm. In about 3-3.5 h it is important to carry out spectral-fluorescent diagnostics (SFD) of metastatic foci and if the ratio of their fluorescence against that of surrounding tissue is not less than 3:1 one should conduct transcutaneous laser irradiation (TLI) of metastatic foci at wave length being correspondent to maximal absorption of light radiation with PS. In 24 h on finishing TLI one should carry out additional laser irradiation. The innovation provides either complete or partial regression of metastases along with considerable decrease of the possibility for dissemination out of metastatic foci. ^ EFFECT: higher efficiency of therapy. ^ 3 cl, 1 ex