摘要 |
A method of manufacturing glimepiride of formula Iwherein trans-4-methylcyclohexylamine pivalate of formula VIIis reacted, either directly or after conversion to trans-4-methylcyclohexylamine or to its another salt, with an alkyl [4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-lH-pyrrol-l yl)carbonyl]amino)ethyl)phenyl]-sulfonyl carbamate of general formula IVwherein R is a Calkyl, giving glimepiride of formula I.trans-4-Methylcyclohexylamine pivalate of formula VII. |