Multi-layered macromolecules that are chemically bonded to solid particulate substrates and methods for their use

摘要

Disclosed herein are multi-layered macromolecules, wherein the layers are covalently bonded together and wherein the macromolecules are covalently bonded to solid particulate substrates; methods for the preparation of such compositions; and methods for their uses in a multitude of end use applications ranging from the purification of waste chemical and metal process streams to the separation and identification of proteins, peptides, and oligionucleotides. Particularly disclosed is a multi-layered macromolecule comprising a base macromolecule chemically bonded to a solid particulate substrate wherein the base macromolecule is selected from the group consisting of: (a) dendrimers and, (b) hyperbranched polymers and, wherein the base macromolecule is surmounted by at least one chemically bound additional layer of macromolecule to form at least one chemically bonded layer on the base macromolecule, wherein the layered macromolecule is selected from the group consisting of : (i) dendrimers and (ii) hyperbranched polymers.