| 摘要 |
An orally deliverable pharmaceutical composition is provided comprising a drug which is a selective cyclooxygenase-2 inhibitory drug having the formulawhereRis a methyl or amino group,Ris hydrogen, a (C-C) alkyl or alkoxy group,X is N or CRwhereRis hydrogen or halogen, andY and Z are independently carbon or nitrogen atoms defining adjacent atoms of a five-to six-membered ring that is unsubstituted or substituted at one or more positions with oxo, halo, methyl or halomethyl groups; or a prodrug of such a compound and a solvent liquid that comprises at least one pharmaceutically acceptable solvent, at least one pharmaceutically acceptable fatty acid and at least one pharmaceutically acceptable organic amine, wherein (a) a substantial portion of the drug, for example at least about 15% by weight, is in dissolved or solubilized form in the solvent liquid, and (b) the fatty acid and the organic amine are present in total and relative amounts such that the composition is finelyself-emulsifiable in simulated gastric fluid. |
