Methods of inducing a cytotoxic immune response and recombinant simian adenovirus compositions useful therein

摘要

A replication defective simian adenoviral vector containing, in a simian adenoviral capsid, simian adenoviral cis-elements and a heterologous gene operably linked to expression control sequences, wherein the simian adenoviral capsid is derived from a chimpanzee adenovirus selected from the group consisting of Pan 5, Pan 6 and Pan 7. Also disclosed is the use of the recombinant simian adenovirus in the preparation of a medicament.