COMPUESTOS DERIVADOS DE [1,6]-NAFTIRIDINONA, MODULADORES DE LA ACTIVIDAD CINASA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; Y SU USO PARA TRATAR TRASTORNOS PROLIFERATIVOS, INFLAMATORIOS, AUTOINMUNE, DEL SISTEMA NERVIOSO CENTRAL, ENTRE OTROS.

摘要

The invention provides compounds of Formula (2), and pharmaceutical compositions thereof, wherein R1, R2, R3, R4 and L are as described herein; as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.