Novel benzomidazole derivatives useful as antiproliferative agents for treating cancer

摘要

Disclosed herein is a compound selected from the group consisting of: (±)-1-{2-[5-(Tetrahydro-furan-3-yloxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine; (+)-1-{2-[5-(Tetrahydro-furan-3-yloxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine; (-)-1-{2-[5-(Tetrahydro-furan-3-yloxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine; 1-{2-[5- (3-Methyl-oxetan-3-ylmethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine; 1-{2-(5-Isobutoxy-benzoimidazol-1-yl)-quinolin-8-yl}-piperidin-4-ylamine; 1-{2-(5-(Tetrahydro-pyran-4-yloxy)-benzoimidazol-1-yl]-quinolin-8-yI}-piperidin-4-ylamine; and the pharmaceutically acceptable salts, prodrugs, hydrates and solvates of the foregoing compounds. These compounds and their pharmaceutical compositions are suitable as antiproliferative agents and may be used for treating abnormal cell growth, such as cancer. The disclosure also relates to methods of preparing such benzomidazole derivative compounds.