Solid pharmaceutical formulation of a piperazine urea derivative used for treating inflammatory diseases

摘要

Disclosed herein is a solid pharmaceutical agent formulation that contains (2R)-1-((4-chloro-2-(ureido)phenoxy)methyl)carbonyl-2-methyl-4-(4-fluorobenzyl)piperazine or a salt thereof, wherein in addition to that, it contains a polymer matrix, an organic acid, a lubricant and one or more adjuvants and in that at least 90% of the particle sizes of the powder mixtures are in the range between 0.1 and 750 micrometers. These solid pharmaceutical agent formulations are suitable for treating inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis and atopic derrnatitis.