发明名称 |
ANTIBODY-BASED THERAPEUTICS WITH ENHANCED ADCC ACTIVITY |
摘要 |
Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.
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申请公布号 |
US2007092521(A1) |
申请公布日期 |
2007.04.26 |
申请号 |
US20060551679 |
申请日期 |
2006.10.20 |
申请人 |
MCPHERSON JOHN M;EDMUNDS TIM;ZHOU QUN |
发明人 |
MCPHERSON JOHN M.;EDMUNDS TIM;ZHOU QUN |
分类号 |
A61K39/395;C07H21/04;C07K16/30;C07K16/46;C07K17/14;C12N5/06;C12P21/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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