发明名称 |
Coated implantable medical device |
摘要 |
A medical device ( 10 ) includes a structure ( 12 ) adapted for introduction into a patient, the structure ( 12 ) being formed of a preferably non-porous base material ( 14 ) having a roughened or textured surface ( 16 ). The structure ( 12 ) is conveniently configured as a vascular stent with a base material ( 14 ) of stainless steel, nitinol or another suitable material. The medical device ( 10 ) also includes a layer ( 18 ) of a bioactive material posited directly upon the roughened or textured surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ). The surface ( 16 ) of the base material ( 14 ) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface ( 16 ) is thought to have a mean surface roughness of about 10 muin. (about 250 nm) and a surface roughness range between about 1 muin. and about 100 muin. (about 25 nm and about 2.5 mum). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface ( 16 ) of the base material ( 14 ) of the structure ( 12 ) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate. |
申请公布号 |
AU2002239436(B2) |
申请公布日期 |
2007.04.26 |
申请号 |
AU20020239436 |
申请日期 |
2001.10.31 |
申请人 |
COOK INCORPORATED;MED INSTITUTE, INC. |
发明人 |
JAMES D PURDY;ANTHONY O RAGHEB;WILLIAM J BOURDEAU;NEAL E FEARNOT;BRIAN D CHOULES;BRIAN, L. BATES;JOSEPH, M., IV STEWART |
分类号 |
A61L29/00;A61F2/00;A61F2/06;A61F2/84;A61F2/86;A61K31/337;A61K31/4545;A61L27/54;A61L31/16;A61P9/10;A61P35/00 |
主分类号 |
A61L29/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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