Use of bivalent or polyvalent trisaccharides as fusion-inhibitors in all HIV types, subtypes, groups, strains, and circulating recombinant forms

摘要

This invention relates to compositions containing bivalent or polyvalent trisaccharides, specifically but not exclusively, melezitose and raffinose, and to their use in the treatment/prevention/cure of HIV and AIDS. In particular, such compositions can be used to competitively inhibit formation of the viral fusion complex. This invention also relates to compositions containing bivalent or polyvalent trisaccharides, specifically but not exclusively, melezitose and raffinose, and to their use in other viral infections such as Influenza and Ebola, and furthermore to their use in the treatment of cancer. This invention also relates to the identification of a formerly unidentified "density" present in the Phe43 cavity of HIV. This invention hereby identifies said density as cholesterol.