Reduction and prevention of cell-associated HIV transepithelial migration, microbides and other formulations and methods

摘要

A vaginal microbicide including scFv-type antibodies reduces or prevents transepithelial HIV transmission. As the antibodies, anti-CD 18 and/or anti-CD 11 antibodies (of the scFv type) are used. Preferably, anti-ICAM antibody also is used. The antibodies may be delivered to the to-be-protected epithelium using a bacterial delivery system such as a lactobacillus bacterial vehicle. HIV transepithelial transmission can thereby be reduced or prevented, including prevention of initial infection.