| 摘要 |
PROBLEM TO BE SOLVED: To provide the preparation, design, derivation, and use of a peptide agonist and an antagonist of a chemokine concerned with pathological condition such as disease and symptom associated with inflammation and autoimmune response. SOLUTION: There are provided chemokine analogs, including IL-8 analogs, IP-10 analogs, MIP-1αanalogs, RANTES analogs, I-309 analogs, MCP-1 analogs, and CCL28 analogs, that are useful for the treatment of a variety of diseases and disorders, and as an adjunct to the treatment of a variety of diseases and disorders. A therapeutically effective amount of the chemokine analog may be administered to a patient in need of such treatment. COPYRIGHT: (C)2007,JPO&INPIT
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