METHODS OF REDUCING REPEAT-INDUCED SILENCING OF TRANSGENE EXPRESSION AND IMPROVED FLUORESCENT BIOSENSORS
摘要
Methods of avoiding repeat- and homology-induced silencing of transgenes are disclosed, in which trangene sequences are genetically altered to reduce the affects of gene silencing. FRET biosensors containing such genetic alterations for improved expression in cell lines and in vivo are disclosed.
申请公布号
WO2007046787(A2)
申请公布日期
2007.04.26
申请号
WO2005US36953
申请日期
2005.10.14
申请人
CARNEGIE INSTITUTION OF WASHINGTON;FROMMER, WOLF, B.;DEUSCHLE, KAREN