MUTATED NONACTIVATING IgG2 DOMAIN AND ANTI-CD3 ANTIBODY INCORPORATING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide an anti-CD3 antibody having mutated constant regions that exhibit mitogenic activity to a still lesser extent and/or in fewer patients than existing antibodies. SOLUTION: The mutated IgG2 constant region comprises a nonnaturally occurring segment of amino acids between residues 234 and 237 defined by the EU numbering system. The antibody comprising a variable region of the anti-CD3 antibody bound to the mutated IgG2 constant region induces the mitogenic response in a human T-cell reduced compared to the second antibody including the variable region of the anti-CD3 antibody linked to the natural IgG2 constant region. COPYRIGHT: (C)2007,JPO&INPIT