发明名称 |
Toremifene crystallization method |
摘要 |
The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solvent, allowing the crystallized product of the previous step to crystallize from a second solvent comprising acetone, methyl ethyl ketone or ethyl acetate, and optionally converting toremifene crystallized from the previous step to a pharmaceutically acceptable salt thereof.
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申请公布号 |
US2007093556(A1) |
申请公布日期 |
2007.04.26 |
申请号 |
US20040557471 |
申请日期 |
2004.05.19 |
申请人 |
TOIVOLA REIJO;HUUHTANEN TUOMAS |
发明人 |
TOIVOLA REIJO;HUUHTANEN TUOMAS |
分类号 |
A61K31/138;C07C213/10;C07C215/46;C07C217/20 |
主分类号 |
A61K31/138 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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