发明名称 Toremifene crystallization method
摘要 The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solvent, allowing the crystallized product of the previous step to crystallize from a second solvent comprising acetone, methyl ethyl ketone or ethyl acetate, and optionally converting toremifene crystallized from the previous step to a pharmaceutically acceptable salt thereof.
申请公布号 US2007093556(A1) 申请公布日期 2007.04.26
申请号 US20040557471 申请日期 2004.05.19
申请人 TOIVOLA REIJO;HUUHTANEN TUOMAS 发明人 TOIVOLA REIJO;HUUHTANEN TUOMAS
分类号 A61K31/138;C07C213/10;C07C215/46;C07C217/20 主分类号 A61K31/138
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