PHTHALAZINONE DERIVATIVES

摘要

A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) where Y¹ is selected from CH and N, Y² is selected from CH and N, Y³ is selected from CH, CF and N; and (ii) and where Q is O or S; R^D is: wherein R^N1 is selected from H and optionally substituted C_1-10 alkyl; X is selected from a single bond, NR^N2, CR^C3R^C4 and C-O; R^N2 is selected from H and optionally substituted C_1-10 alkyl; R^C3 and R^C4 are independently selected from H, R, C(-O)OR, where R is optionally substituted C_1-10 alkyl, optionally substituted C_5-20 aryl or optionally substituted C_3-20 heterocyclyl; Y is selected from NR^N3 and CR^C1R^C2; R^C1 and R^C2 are independently selected from H, R, C(-O)OR, where R is optionally substituted C_1-10 alkyl, optionally substituted C_5-20 aryl or optionally substituted C_3-20 heterocyclyl; R^C1 and R^C2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C_5-7 carbocylic or heterocyclic ring; and when X is a single bond R^N1 and R^C2 may together with the N and C atoms to which they are bound, form an optionally substituted C_5-7 heterocylic ring; and when X is CR^C3R^C4, R^C2 and R^C4 may together form an additional bond, such that there is a double bond between the atoms substituted by R^C1 and R^C3.