Pharmaceutical compositions for the treatment of organophosphate poisoning

摘要

A pharmaceutical composition comprising (i) a carbamate; (ii) a first anticholinergic; (iii) a second anticholinergic; and (iv) a pyridinium salt. The pharmaceutical composition is suitable for the treatment of organophosphate poisoning, including nerve agent and pesticide poisoning. The pharmaceutical composition provides an effective therapy against the lethal effects of nerve agent, provides effective protection from the effects of incapacitation and does not require the use of a pre-treatment. A kit comprising the pharmaceutical composition is also described and claimed.