发明名称 |
METHOD FOR STABILIZATION OF ISOXAZOLE COMPOUND |
摘要 |
<p>3-[(1S)-1-(2-fluorobiphenyl-4-yl)ethyl]-5-[[amino(morpholin-4-yl)methylene]amino]isoxazole is an isoxazole compound useful as a therapeutic agent for an autoimmune disease. The isoxazole compound can be stabilized by using an antioxidant such as a pyrosulfurous acid salt, a bisulfite salt, a sulfurous acid salt or dibutylhydroxytoluene. A pharmaceutical composition for oral administration comprising the isoxazole compound and the antioxidant is an excellent pharmaceutical composition, since the isoxazole compound contained in the composition is stabilized.</p> |
申请公布号 |
WO2007046411(A1) |
申请公布日期 |
2007.04.26 |
申请号 |
WO2006JP320732 |
申请日期 |
2006.10.18 |
申请人 |
DAINIPPON SUMITOMO PHARMA CO., LTD.;NISHII, HIROYUKI;MATSUOKA, MAKOTO |
发明人 |
NISHII, HIROYUKI;MATSUOKA, MAKOTO |
分类号 |
A61K47/14;A61K47/16;A61K47/20;A61K47/22;A61K47/26;A61K47/32;A61K47/36;A61K47/38;A61K47/44;A61P29/00;A61P37/02;A61K9/16;C07D261/14;A61K9/20;A61K9/28;A61K31/5377;A61K47/02;A61K47/10;A61K47/12 |
主分类号 |
A61K47/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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