发明名称 |
Production of humanized antibodies in transgenic animals |
摘要 |
This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.
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申请公布号 |
US2007092505(A1) |
申请公布日期 |
2007.04.26 |
申请号 |
US20060584187 |
申请日期 |
2006.10.20 |
申请人 |
BUELOW ROLAND;PLATZER JOSEF;SCHOOTEN WIM V;BUELOW JENS-ULRICH |
发明人 |
BUELOW ROLAND;PLATZER JOSEF;SCHOOTEN WIM V.;BUELOW JENS-ULRICH |
分类号 |
A61K39/395;A01K67/027;C07K16/00;C07K16/08;C07K16/12;C07K16/44;C12N15/85 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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