发明名称 |
RNAi-based modification of the heterochromatin |
摘要 |
Methods of regulating the formation of heterochromatin at a target locus within the genome of a cell and methods of regulating the modification of a histone protein assumed on the DNA of a target locus within the genome of a cell are provided. In particular, the invention provides methods to regulate the structure of the genome of a cell, where the structure is regulated by modulating heterochromatin formation, heterochromatin architecture, histone methylation, and/or DNA methylation, by exposing the cell to an RNAi probe complementary to a target locus so as to activate the RNAi machinery to modify the genomic structure of the target locus and adjacent segments of the genome. |
申请公布号 |
ZA200601596(B) |
申请公布日期 |
2007.04.25 |
申请号 |
ZA20060001596 |
申请日期 |
2006.02.23 |
申请人 |
COLD SPRING HARBOR LABORATORY |
发明人 |
GREWAL, SHIVINDER, S.;HALL, IRA, M.;MARTIENSSEN, ROBERT A.;VOLPE, THOMAS;KIDNER, CATHERINE |
分类号 |
A61K48/00;C12N;C12N15/113;C12N15/63 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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