Pyrimidine-2,4-dione derivatives as gonadotripin-releasing hormone receptor antagonists

摘要

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R_1a, R_1b, R_1c, R_2a, R_2b, R₃, R₄, R₅, R₆ and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.