发明名称 |
Pyrrole-2,5-dione derivatives as Liver X receptor modulars |
摘要 |
The present invention relates to certain novel compounds of the Formula I to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR)alpha(NR1H3) and/or beta(NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them. |
申请公布号 |
ZA200600222(B) |
申请公布日期 |
2007.04.25 |
申请号 |
ZA20060000222 |
申请日期 |
2006.01.10 |
申请人 |
ASTRAZENECA AB. |
发明人 |
BOSTROEM, JONAS;HOLM, PATRICK;SWANSON, MARIANNE;BRICKMANN, KAY;SANDBERG, PEMILLA;WESTERLUND, CHRISTER |
分类号 |
A61K;A61K31/4025;A61K31/4439;A61P;A61P3/10;A61P25/28;C07D;C07D207/416;C07D207/44;C07D207/456;C07D401/06;C07D405/06;C07D405/12;C07D405/14;C07D413/06 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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