| 主权项 |
1. A computer-implemented method of evaluating a patient with vascular disease, the method comprising:
receiving a tissue model of the patient; receiving a vascular model defining one or more vessel pathologies at a location of vasculature supplying blood to the tissue model; modeling perfusion resulting from a first vessel pathology of the vascular model supplying blood to at least a portion of the tissue model; computing, from the modeled perfusion resulting from the first vessel pathology, a first tissue characteristic value of the tissue model in response to the first vessel pathology, the tissue characteristic including a measure of tissue viability, a tissue capacity to change blood flow, a tissue irregularity, a tissue electrical property, and/or a tissue mechanical property; modeling perfusion resulting from a second vessel pathology of the vascular model supplying blood to at least a portion of the tissue model; computing, from the modeled perfusion resulting from the second vessel pathology, a second tissue characteristic value of the tissue model in response to the second vessel pathology; determining an effect of vessel pathology on the at least one tissue characteristic, from a comparison of the first tissue characteristic to the second tissue characteristic; receiving an observed tissue characteristic value associated with a patient; and estimating, using one or more computer processors, one or more patient pathological characteristics at a location in the patient's anatomy using the observed tissue characteristic value and the determined effect of the vessel pathology on the at least one tissue characteristic. |
