| 摘要 |
<p>This invention is directed to compounds of formula la, lb or Ic and to pharmaceutical compositionsthereof: formula (Ia), formula (Ib), formula (Ic) or a prodrug thereof and a pharmaceuticallyacceptable carrier, wherein the R groups are defined in the specification; and,in which the dashed line represents an optional double bond. The invention isalso directed to methods of treating, diagnosing, and preventing disordersof the central nervous system that are associated with 5HT receptors, includingobesity, attention deficit disorder, migraine, depression, epilepsy, anxiety,Alzheimer's disease, withdrawal from drug abuse, pain, schizophrenia,stress-related disorders, panic disorder, sleep disorders, phobias, obsessivecompulsive disorder, post-traumatic-stress syndrome, immune system depression,stress-induced gastrointestinal dysfunction, stress-induced cardiovasculardysfunction, and sexual dysfunction.</p> |
