发明名称 |
STABILIZED GAS EMULSION CONTAINING PHOSPHOLIPID FOR ULTRASOUND CONTRAST ENHANCEMENT |
摘要 |
A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5 % w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.</S DOAB>
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申请公布号 |
CA2212113(C) |
申请公布日期 |
2007.04.24 |
申请号 |
CA19962212113 |
申请日期 |
1996.02.15 |
申请人 |
ALLIANCE PHARMACEUTICAL CORP. |
发明人 |
TREVINO, LEO A.;SCHUTT, ERNEST GEORGE;KLEIN, DAVID H.;KABALNOV, ALEXEY;WEERS, JEFFRY G.;TARARA, THOMAS E. |
分类号 |
A61K9/127;B01J13/00;A61B8/00;A61K49/00;A61K49/22 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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