Substituted triazole derivatives as oxytocin antagonists

摘要

The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.;

主权项

1. A compound of formula (I): wherein:
m is 2 and n is 1;X is selected from O, NH, N(C1-C6)alkyl, NC(O)(C1-C6)alkyl, N(SO2(C1-C6)alkyl), S and SO2;R1 is phenyl or napthylwherein said phenyl or napthyl is optionally substituted with one or more substituents independently selected from halo, (C1-C6)alkyl, (C1-C6)alkoxy,(C1-C6)alkoxy(C1-C6)alkyl, cyano, CF3, NH(C1-C6)alkyl, N((C1-C6)alkyl)2, CO(C1-C6)alkyl, C(O)O(C1-C6)alkyl, C(O)NH(C1-C6)alkyl, C(O)N((C1-C6)alkyl)2, C(O)OH and C(O)NH2;R2 is selected from:(i) H and hydroxy;(ii) (C1-C6)alkyl, which is optionally substituted by O(C1-C6)alkyl or phenyl;(iii) O(C1-C6)alkyl, which is optionally substituted by O(C1-C6)alkyl;(iv) NH(C1-C6)alkyl, said alkyl group being optionally substituted by O(C1-C6)alkyl; and(v) N((C1-C6)alkyl)2, one or both of said alkyl groups being optionally substituted by O(C1-C6)alkyl;R3 is selected from H, (C1-C6)alkyl and (C1-C6)alkoxy(C1-C6)alkyl;R4, R5, R6 and R7 are each independently selected from H, halo, hydroxy, CN, (C1-C6)alkyl, NH(C1-C6)alkyl, N((C1-C6)alkyl)2 and O(C1-C6)alkyl;R8 is selected from H, (C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, CH2OH, CH2NH2, CH2NH(C1-C6)alkyl, CH2N((C1-C6)alkyl)2, CN, C(O)NH2, C(O)NH(C1-C6)alkyl and C(O)N((C1-C6)alkyl)2; a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.