| 发明名称 |
STING CRYSTALS AND MODULATORS |
| 摘要 |
The present invention provides STING crystals. The present invention also provides STING modulators that interact with sites present in and/or defined by such crystals. The present invention also provides methods of making and using such crystals and modulators. Other aspects and/or features of the present invention will be apparent to those skilled in the art, reading the present specification. |
| 申请公布号 |
US2016210400(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201414908019 |
申请日期 |
2014.07.31 |
| 申请人 |
MEMORIAL SLOAN-KETTERING CANCER CENTER ;THE ROCKEFELLER UNIVERSITY ;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ;UNIVERSITY OF BONN |
发明人 |
Patel Dinshaw J.;Tuschl Thomas;Jones Roger;Hartmann Gunther;Barchet Winfried;Zillinger Thomas;Wang Weiyi;Gao Pu;Deng Liang;Ascano, JR. Manuel |
| 分类号 |
G06F19/16;G01N33/68;G06F19/12;C07K14/715 |
主分类号 |
G06F19/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A STING modulator whose structure is an analog of c[G(2′,5′)pA(3′,5′)p], DMXAA, or CMA, and includes a moiety that interacts with a residue corresponding to Gly230, Gln266, Ser162, or Ile165 of hSTING, or a combination thereof. |
| 地址 |
New york NY US |
