发明名称 |
Pharmaceutical compositions including variants of vascular endothelial cell growth factor having altered pharmacological properties |
摘要 |
Described herein are pharmaceutical compositions including vascular endothelial cell growth factor (VEGF) variants having structural alterations in the C-terminal heparin binding domain and methods of use. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with native VEGF thus providing variants having longer availability for therapeutic effect.
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申请公布号 |
US7208472(B2) |
申请公布日期 |
2007.04.24 |
申请号 |
US20020200050 |
申请日期 |
2002.07.19 |
申请人 |
GENENTECH, INC. |
发明人 |
ZIONCHECK THOMAS F.;DEGUZMAN GERALYN G.;KECK RODNEY GENE |
分类号 |
C07K14/475;A61K38/00;A61K38/18;C07K14/52;C12N15/18 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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