Process for the reductive amination of ketones and aldehydes with aqueous amines

摘要

Amine preparation comprises catalytic hydrogenating amination of carbonyl compound with nitrogen compound in the presence of bifunctional catalyst. The bifunctional catalyst comprises hydrogenation-active catalyst component. The hydrogenation-active catalyst component comprises metal(s) of transition group 8 of the Periodic Table, and solid acidic cocatalyst(s). The hydrogenating amination is carried out in a reaction mixture in the presence of aqueous solution. The aqueous solution is aqueous ammonia or amine, and organic solvent(s) miscible with ammonia or amine. Amines preparation of structure R1>R2>CHNR3>R4> comprises catalytic hydrogenating amination of carbonyl compound of structure R1>-C(O)R->2 with nitrogen compound of structure HNR3>R4> in the presence of bifunctional catalyst. The bifunctional catalyst comprises hydrogenation-active catalyst component. The hydrogenation-active catalyst component comprises metal(s) of transition group 8 of the Periodic Table, and solid acidic cocatalyst(s). The hydrogenating amination is carried out in a reaction mixture in the presence of aqueous solution. The aqueous solution is aqueous ammonia or III, and organic solvent(s) miscible with ammonia or III. R1>-R4>H, straight-chain or branched, halogenated or halogen-free 1-12C alkyl, 3-12C-cycloalkyl, 6-10C aryl, or 7-11C-aralkyl.