Placental tissue grafts

摘要

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

主权项

1. A dehydrated, laminated bilayer tissue graft consisting essentially of
a) a washed, cleaned and dehydrated amnion layer isolated from a placenta; b) a washed, cleaned and dehydrated chorion layer isolated from a placenta; wherein the amnion layer has a first side which is an exposed basement membrane and a second side which is a fibroblast layer, and further wherein the chorion is in direct contact with the amnion and the two layers are laminated together.