DEGLYCOSYLATED KRINGLE 1-5 REGION FRAGMENTS OF PLASMINOGEN AND METHODS OF USE
摘要
<p>Disclosed are deglycosylated fragments of a kringle 1-5 region of plasminogen, nucleotides encoding deglycosylated kringle 1-5 region proteins and antibodies specific for deglycosylated kringle 1-5 region proteins. The compositions of the present invention have increased antiangiogenic activity as compared to previously isolated kringle 1-5 region proteins. Also included in the present invention are methods of treating angiogenesis-associated diseases and conditions such as cancer using the compositions described herein.</p>
申请公布号
EP1153125(B1)
申请公布日期
2007.04.18
申请号
EP20000908590
申请日期
2000.02.10
申请人
THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人
PIRIE-SHEPHERD, STEPHEN;FOLKMAN, M., JUDAH;LIANG, HONG;MACDONALD, NICHOLAS, J.;SIM, KIM, LEE
