COMPOSITIONS COMPRISING AMPHOTERICINB METHODS AND SYSTEMS

摘要

A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 mum to about 1.9 mum. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 mum to about 1.9 mum. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 mum, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.