CIRCUIT ARCHITECTURE AND SYSTEM FOR IMPLANTABLE MULTI-FUNCTION AND MULTI-ANALYTE BIOSENSING DEVICE

摘要

An implantable bio-sensing platform architecture that enables the wireless selection, calibration and reading of multiple sensors, as well as checking the power levels of the solar powering source energizing various electronic and optoelectronic devices and circuits embedded in the platform. It also permits checking the operation of the potentiostats interfacing with each amperometric analyte sensor. The platform is flexible to include FET based sensors for protein sensing as well as other applications including pH sensing. In addition, other physiological sensors can be integrated in the platform.

主权项

1. An implantable bio-sensing platform chip that enables the wireless selection, calibration and reading of multiple sensors, wherein the bio-sensing platform receives optical power and coded optical instructions from an external control unit located in proximity of the implanted sensor platform chip, the bio-sensing platform comprising:
sensors, sensor interface circuits, signal processors, electronic multiplexers, solar cells, and optoelectronic transmitters and receivers that wirelessly communicates with said external unit, wherein the platform receives from the optical transmitter located in the external control unit coded pulses using at least one photodetector operating at the dedicated wavelength and converting them to electrical pulses, wherein solar cells are interfaced with at least one voltage regulator circuit whose output provides stable power to the entire platform electronic circuits and optoelectronic transmitters and receivers, and a radio frequency (RF) transmitter wherein the carrier wave is modulated depending on the output of signal processing unit and transmitting RF waves using an antenna located on the biosensing platform, and where in the RF wages are received by the RF receiver located in the external unit, wherein coded electrical pulses are decoded using finite state machine architecture by the mode select unit interfacing with the said photodetector receiving the coded pulses, wherein mode select unit comprising of logic circuits enabling various functions depending on the code pulses, wherein coded pulse sequence in one code enables operation of checking solar power output providing information regarding the level of electrical power generated by the solar cells by sending a dedicated frequency voltage pulse train which drives a voltage controlled oscillator serving as a FM transmitter or a dedicated RF transmitter with a specific frequency range and located on the implanted platform, wherein the output of the FM transmitter is transmitted using an antenna located on the bio-sensing platform, wherein coded pulse sequence in one embodiment enables checking of operation of a potentiostat interfacing with a bio-sensing element before bio-sensing element code is sent for taking readings, wherein the output of said voltage controlled oscillator or a FM transmitter is received by a dedicated FM receiver located in the external control unit, and wherein FM receiver in the external control unit output is processed and displayed, wherein coded pulse sequence in another coded sequence enables calibration and reading of a designated biosensor, wherein the bio-sensing platform sensors include analytic sensors, protein biosensors, and physiological sensors, the analyte sensors being connected to interface electronics, signal processing unit, and multiplexer, and wherein the multiplexer output feeds a driver that in turn feeds the said FM transmitter which converts electrical pulses into FM pulses.