ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE

摘要

The present invention relates to the prediction of antipsychotic treatment efficacy based on a patient's genotype at one or more single nucleotide polymorphism (SNP) loci and to the treatment of a patient based on such prediction.

主权项

1. A method comprising:
determining an individual's genotype at a single nucleotide polymorphism (SNP) locus rs875326; in the case that the individual's genotype at the rs875326 SNP locus is non-AG:
predicting that treating the individual with an atypical antipsychotic will be efficacious; andtreating the individual with a dose of between about 2 mg/day and about 24 mg/day of iloperidone, a pharmaceutically-acceptable salt thereof, a metabolite thereof, or a pharmaceutically-acceptable salt of a metabolite thereof; and in the case that the individual's genotype at the rs875326 SNP locus is AG:
predicting that treating the individual with an increased dose of an antipsychotic would be efficacious, wherein the increased dose is a greater dose than would be used to treat an individual with a non-AG genotype at the rs875326 SNP locus; andtreating the individual with an increased dose of between about 24 mg/day and about 50 mg/day of iloperidone, a pharmaceutically-acceptable salt thereof, a metabolite thereof, or a pharmaceutically-acceptable salt of a metabolite thereof.