PROCESS FOR IMPROVED PROTEIN EXPRESSION BY STRAIN ENGINEERING
摘要
<p>This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.</p>
申请公布号
EP1774017(A2)
申请公布日期
2007.04.18
申请号
EP20050774619
申请日期
2005.07.26
申请人
DOW GLOBAL TECHNOLOGIES INC.
发明人
RAMSEIER, THOMAS, M.;JIN, HONGFAN;SQUIRES, CHARLES, H.