Cellulosic gel material as a pharmaceutical excipient

摘要

A method of making a pharmaceutical tablet comprises (a) combining (i) an aqueous networked cellulose gel with (ii) filler and (iii) an active agent to form a mixture thereof; (b) casting the mixture to form a wet tablet; (c) drying the wet tablet to form a dry pharmaceutical tablet; and then (d) optionally coating the tablet (e.g., with an enteric coating). Pharmaceutical tablets produced by such methods are also described.

主权项

1. A method of making a pharmaceutical tablet, comprising:
(a) producing an aqueous networked cellulose gel by: (i) hydrolyzing cellulose in an acidic dissolution media at a temperature of 5 to 40° C. for 10 to 60 minutes to form a first mixture; (ii) precipitating said hydrolyzed cellulose by combining said first mixture with an antisolvent, and then, in any order; (iii) separating said cellulose precipitate from said antisolvent and acidic dissolution media; (iv) adjusting or neutralizing the pH of said cellulose precipitate to a pH of from 4 to 9; and (v) washing said cellulose precipitate with water to form said aqueous networked cellulose gel; (b) combining (i) said aqueous networked cellulose gel with (ii) water insoluble particulate filler and (iii) a water soluble active agent to form a mixture thereof; (c) casting said mixture to form a wet tablet; (d) drying said wet tablet to form a dry pharmaceutical tablet; and then (e) optionally coating said tablet.