发明名称 |
Anti-CD3 antibody for the use in the induction of immunosuppression |
摘要 |
The invention provides bispecific antibodies with selective cytoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific components of the bispecific antibodies, humanized versions thereof, and humanized bispecific antibodies. The invention further provides therapeutic and diagnostic methods employing these antibodies.
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申请公布号 |
EP1775307(A2) |
申请公布日期 |
2007.04.18 |
申请号 |
EP20060076573 |
申请日期 |
1996.02.29 |
申请人 |
PDL BIOPHARMA, INC.;IOWA IMMUNOTHERAPY INVESTIGATORS |
发明人 |
WEINER, GEORGE;GINGRICH, ROGER;LINK, BRIAN;TSO, J YUN |
分类号 |
C07K16/28;C12N15/02;A61K38/00;A61K39/395;A61K49/00;A61P35/00;C07K16/16;C07K16/30;C07K16/46;C12N5/10;C12N5/12;C12N5/16;C12N5/18;C12N5/20;C12N15/13;C12P21/04;C12P21/08;C12R1/91 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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