发明名称 |
Methods of treating insulin resistance with an inhibitor of an NAD(P)H oxidase |
摘要 |
The present invention relates to the use of NAD(P)H oxidase inhibitors to increase cellular uptake of glucose and in the treatment and/or prevention of diseases caused by insulin resistance or diseases related thereto, such as type II diabetes. Specifically, the invention relates to a method for identifying an agent useful for the treatment or prophylaxis of a medical condition associated with elevated levels of blood glucose, the method comprising (i) contacting a candidate agent with a mammalian NAD(P)H oxidase or NAD(P)H oxidase complex; and (ii) determining whether said candidate agent inhibits the biological activities of the NAD(P)H oxidase or NAD(P)H oxidase complex.
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申请公布号 |
US7205127(B2) |
申请公布日期 |
2007.04.17 |
申请号 |
US20050069161 |
申请日期 |
2005.02.28 |
申请人 |
GLUCOX AB |
发明人 |
GROENBERG ALVAR;WIKSTROEM PER |
分类号 |
C12N15/09;A61K31/03;A61K31/12;A61K31/255;A61K31/265;A61K31/305;A61K31/4164;A61K31/44;A61K45/00;A61P3/10;A61P43/00;C12N5/06;C12Q1/02;C12Q1/26;G01N33/66;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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