ADENOVIRUS VECTORS FOR GENE THERAPY

摘要

The invention comprises a series of adenovirus-based vectors having deletion s in the E1 and/or E3 regions, and optionally insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts into host cells, tissues or organisms that then can express the insert. The invention also comprises the use of these vectors in introducing genes into cells, in making vaccines and in gene therapy.