BIOCOMPATIBLE COMPOSITIONS

摘要

A polymer is formed from monomers including a zwitterionic monomer, a cation ic monomer and a hydrophobic termonomer. The polymer may be cross-linkable. The polymer may be coated onto a surface from a liquid coating composition followed by contacting the coated surface with heparin. The double coated substrates have improved heparin activity over extended periods as compared to heparinised surfaces which are commercially available. Other anionically charged mucopolysaccharides may be used. The polymers may also scavenge heparin from treated blood to avoid use of potentially toxic heparin inhibitors. Preferably the terpolymer is formed from 2-methacryloyloxyethyl-2-(trimethylamonium)phosphate inner salt, choline methacrylate and n-dodecyl methacrylate.