| 摘要 |
<p>The present invention relates to methods for treating a patient suffering from diseases or disorders of the central nervous system associated with the disturbance of the human circadian clock that are ameliorated by inhibition of casein kinase I activity such as , for example, mood disorders including major depressive disorder, bipolar I disorder and bipolar II disorder, and sleep disorders including circadian rhythm sleep disorders such as, for example, shift work sleep disorder, jet lag syndrome, advanced sleep phase syndrome and delayed sleep phase syndrome, with 3-arylthioindole-2-carboxamides, 5-substituted-3-arylthioindole-2-carboxamides and related analogues.</p> |
