AMINO-TROPANE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF.

摘要

The invention concerns amino-tropane derivatives of general formula (I), wherein:Ra R a' et R5 represent hydrogen atoms oralkyl groups; R1 represents a hydrogen atom or an alkyl, cycloalkyl,heterocycloalkyl or aryl group; R2 represents a group of formula -(CH2)x-(CO)y-Yor -(CO)y-(CH2)x-Y, wherein Y represents a hydrogenatom or a hydroxy, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl group or NR11R12;R3 represents 1 to 3 groups selected among halogen atoms and alkyl,cycloalkyl OR, -NRR', -CO-NRR', -NR-CO-R', -NR-CO-NRR',-NR-COOR', -NO2, -CN and -COOR groups; R4 is selectedamong a group of formula (a), (b), (c) or (d): or a group of formula -A-R18,-A-CH=N-R19, -A-N(R20)-A'-R19, -A-CO-N(R2O)-A'-R19,-A-CH(NH2)-R19, -A-N(R20)-COO-A' or-(CH2)r-heteroaryl. The invention also concerns a method for preparingsaid derivatives and the therapeutic use thereof.