摘要 |
There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R<SUB>1</SUB>, R<SUB>2</SUB>. R<SUB>3</SUB>, R<SUB>4</SUB> and R<SUB>5</SUB> as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by Beta-secretase and, more specifically, inhibit the production of ABeta-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to Beta-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity. |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;GERRITZ, SAMUEL;ZHAI, WEIXU;SHI, SHUHAO;ZHU, SHIRONG;GOOD, ANDREW C.;THOMPSON, LORIN, A., III |
发明人 |
GERRITZ, SAMUEL;ZHAI, WEIXU;SHI, SHUHAO;ZHU, SHIRONG;GOOD, ANDREW C.;THOMPSON, LORIN, A., III |