METHOD OF IDENTIFYING MEMBRANE LG SPECIFIC ANTIBODIES AND USE THEREOF FOR TARGETING IMMUNOGLOBULIN-PRODUCING PRECURSOR CELLS
摘要
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell -mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells.
申请公布号
WO2007041171(A2)
申请公布日期
2007.04.12
申请号
WO2006US37724
申请日期
2006.09.28
申请人
MEDIMMUNE, INC.;WU, HERREN;KIENER, PETER;CHOWDHURY, PARTHA, S.;YOUNG, JAMES, F.
发明人
WU, HERREN;KIENER, PETER;CHOWDHURY, PARTHA, S.;YOUNG, JAMES, F.