发明名称 |
Method for inducing a specific rnai activity in cells and nucleic acids for carrying out said method |
摘要 |
A method for inducing activity of a specific RNAi into eukaryote cells in which the TAT protein and a nucleic acid coding for a nucleotide sequence comprising the sense and antisense sequences of an RNAi of interest are introduced, which sense and antisense sequences are separated by a separating nucleotide sequence coding for a sequence comprising at least the minimal TAR sequence recognized by the TAT protein, which transcribed separating sequence and the TAT protein form a complex that inhibits the activity of the RNAi of interest, and the activity of the RNAi is induced by withdrawing the TAT protein.
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申请公布号 |
US2007082864(A1) |
申请公布日期 |
2007.04.12 |
申请号 |
US20040576390 |
申请日期 |
2004.10.19 |
申请人 |
HAREL-BELLAN ANNICK;AIT-SI-ALI SLIMANE;BENKIRANE MONSEF |
发明人 |
HAREL-BELLAN ANNICK;AIT-SI-ALI SLIMANE;BENKIRANE MONSEF |
分类号 |
A61K48/00;C07H21/04;C12N15/11;C12N15/113;C12N15/63;C12N15/86 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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地址 |
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