发明名称 |
9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS |
摘要 |
The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R<SUP>1</SUP> is H or C<SUB>1-5</SUB>alkyl; X is O or NR<SUP>2</SUP>, wherein R<SUP>2</SUP> is H, C<SUB>1-5</SUB>alkyl or C<SUB>2-5</SUB>acyl and Ar is C<SUB>6-10</SUB>aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R<SUP>3</SUP>-R<SUP>5</SUP> independently selected from halogen, C<SUB>1-5</SUB>alkyl, C<SUB>1-5</SUB>alkoxy, C<SUB>3-6</SUB>cycloalkyl, C<SUB>2-5</SUB>alkenyl, C<SUB>2-5</SUB>alkynyl, CN, NO<SUB>2</SUB>, hydroxy, phenyl, phenoxy and phenylC<SUB>1-2</SUB>alkoxy, wherein said C<SUB>1-5</SUB>alkyl and C<SUB>1-5</SUB>alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC<SUB>1-2</SUB>alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R<SUP>3</SUP>-R<SUP>5</SUP> at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy. |
申请公布号 |
WO2007039563(A1) |
申请公布日期 |
2007.04.12 |
申请号 |
WO2006EP66896 |
申请日期 |
2006.09.29 |
申请人 |
N.V. ORGANON;BINGHAM, MATILDA, JANE;HUGGETT, MARGARET, JEAN;HUGGETT, MARK;KIYOI, YASUKO;NAPIER, SUSAN, ELIZABETH;NIMZ, OLAF |
发明人 |
BINGHAM, MATILDA, JANE;HUGGETT, MARGARET, JEAN;HUGGETT, MARK;KIYOI, YASUKO;NAPIER, SUSAN, ELIZABETH;NIMZ, OLAF |
分类号 |
C07D451/14;A61K31/439;A61P25/24 |
主分类号 |
C07D451/14 |
代理机构 |
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