| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for treating diseases accompanying destruction of bone and to obtain a therapeutic agent. <P>SOLUTION: Destruction of bone is suppressed by making osteoclast differentiation inhibitory action of IL-4 directly act on monocytes being precursor cells of osteoclasts by modified adeno-associated virus incorporated with DNA of human interleukin-4. The osteoclast differentiation inhibitor is useful as a therapeutic agent for rheumatoid arthritis, periodontal disease, osteoporosis, etc. <P>COPYRIGHT: (C)2007,JPO&INPIT |
